In Vivo Sr. Biologist-Insulin/Insulin Signaling

Company: Eli Lilly and Company
Location: Indianapolis
Posted on: January 31, 2026

Job Description:

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. The Cardiometabolic Research Division (CMR) of Eli Lilly and Company, focuses on the discovery of biologic, small molecules, and genetic therapeutics for the treatment of diabetes, obesity and associated complications. We are seeking a skilled and motivated individual who can help build a highly collaborative, successful drug discovery team in the Insulin/Incretin Discovery research group in Indianapolis. The successful candidate will leverage their strong in vivo pharmacology background and complementary laboratory skills to play a critical role in supporting discovery efforts and established pipeline projects with an emphasis on metabolic therapeutics. You will be responsible for setting up critical capabilities in the laboratory setting and working with other scientists within and across departments to achieve project and department goals. This position will primarily involve in vivo compound testing in various rodent models of diabetes, obesity and cardio-metabolic disease. Key responsibilities include: Participation in the development, optimization and validation of in vivo experiments and aid in understanding in vivo biology of target engagement. Active involvement in multiple diabetes and obesity target teams. Perform acute and chronic in vivo studies, glucose/insulin tolerance tests and glycemic clamp studies using radioactive isotopes, including animal handling, blood and biopsy collection, measurement of body weight and food intake as well as test article formulation and administration by oral and parenteral routes. Analysis of data in these experiments including presentation of data in spreadsheet and graphical form with descriptive statistical analysis. Perform small animal surgical procedures including, but not limited to, rodent blood vessel catheterization, telemetry implantation, and mini pump implantation. Minimum requirements: Bachelor's degree or Associates Degree - biology/animal science/veterinary technology or a closely related field Experience in the handling of small laboratory animals Flexible scheduling is a necessity. The position is full-time (40 hrs/wk), but there is a monthly requirement to work as early as 5:00 AM Qualified candidates must be legally authorized to be employed in the United States. Lilly does not anticipate providing sponsorship for employment visa status (e.g., H-1B or TN status) for this employment position Additional Skills/Preferences: Applicant should be able to arrange, modify and organize methods for in vivo studies and modify procedures when warranted. Strong relationship-building, collaboration, and communication skills within the laboratory team. Experience with rodent metabolic disease models, with some knowledge of small animal surgery techniques. Familiarity in the design and execution of the glycemic clamp technique. Knowledge of routine in vitro skills. Ability to multi-task across diverse activities. Strong relationship-building and interaction skills with cross-functional teams and projects. Experience working with radioisotopes, chemical, and biological hazards. Additional experience in cell culture and molecular/biochemical techniques would be a plus. Strong communication skills and experience presenting data in a team environment. This position requires extended periods of standing and the ability to lift 30 lbs. Other Information: The position level will be commensurate with candidate’s experience. The position is governed by regulations including OSHA, AAALAC, OLAW and NRC – compliance to all applicable regulations is mandatory. Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups. Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $65,250 - $169,400 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. WeAreLilly

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