Senior Principal Scientist (R3-R4)

Company: Eli Lilly and Company
Location: Indianapolis
Posted on: April 1, 2026

Job Description:

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. Eli Lilly and Company seeks a Senior Principal Scientist (R3-R4) to execute experiments on the cutting edge of pharmaceutical sciences. Support research programs for identified targets. Oversee aspects of portfolio programs independently by demonstrating laboratory expertise with biologic assays aimed at drug development (mAb, ADC, and CD3 platforms). Perform assay development for specialized assays related to portfolio programs. Perform functional mAb screening and profiling. Conduct evaluation of both in vitro and ex vivo assays. LI-DNI Position requires a Master’s degree in Biomedical Engineering, Bioengineering, or a related field, and 2 years of experience with drug development with mAb, ADC, and CD3 platforms. Experience must include a minimum of: 1 year of experience with phenotypic screens using human myeloid cells to identify novel immuno-oncology targets; 1 year of experience designing and implementing cellular assays to generate subsets of myeloid cells; 1 year of experience using multi-color flow cytometry, NanoString nCounter, and RASL sequencing to characterize myeloid culture systems; and 1 year of experience developing and optimizing flow cytometry, ELISA, and 32-plex Luminex based functional assays to validate the response of protein-based cancer vaccines in murine and cynomolgus models. Part-time telecommuting permitted. LI-DNI Job location: New York, NY To apply, please visit https://jobsearch.lilly.com/ and enter job requisition number R-103515 when prompted. Alternatively, please send your resume, cover letter, and a copy of the ad to: Matthew Tenaglio, Lilly Corporate Center, Indianapolis, IN 46285. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups. Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $105,997.00 - $187,000.00 per year Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. WeAreLilly

Keywords: Eli Lilly and Company, Kokomo , Senior Principal Scientist (R3-R4), Healthcare , Indianapolis, Indiana